In the article is explored some opportunities and mechanisms of ensuring and strengthen the national security of the Republic of Moldova. The European Union can become a major player able to contribute at the ensuring the sub-re-gional security, under the Foreign Policy and Common Security and the partici-pation in the negotiation on finding the solutions to conflict in the eastern regi-on, a significant role is attributed to adjacent sub-structures. Also, the authori-ties of the Republic of Moldova need to be more persistent and demonstrate to the European partners, and to the Euro-Atlantic partners that the democratic reforms policy is irreversible and deserves to be part of the united European fa-mily, engaged in providing security and certainty. Through the competition by the European Union and the North Atlantic Organization, the Republic of Moldova will be able to solve the existent prob-lems of security, but also is important for European partners to participate mo-re actively in the negotiations and to contribute to the ensuring the national in-terest of the Republic of Moldova.