The article was focused on determining the economic efficiency and arguing the economic calculations connected with the economic efficiency of breeding swine for meat within the agricultural farms of the Republic of Moldova. In order to make an analysis, the authors proposed the idea of creating a model farm breeding 30 sows. This example represents an estimation of the entrepreneurs’ possibilities who want to set up such a farm that would include the whole reproduction cycle till the sale of the fattened swine for slaughter. The economic calculations for swine breeding and fattening have been done taking into consideration the following aspects: assessment of the necessary investments, calculation of the annual consumptions, planning annual revenues from sales and calculation of the final economic results. As a result of practicing the entrepreneurship activity within this farm designed for swine breeding and fattening, we determined that it is possible to obtain a sufficient profit for the further development of the mentioned business.