Objectives. To determine the seroprevalence level of viral hepatitis markers A, B, C, and E in patients from the urology department of the Republican Clinical Hospital. Material and methods. A crosssectional descriptive epidemiological study was conducted. Blood samples were collected from patients in the urology department of the Clinical Emergency Hospital (SCR) and examined using enzyme-linked immunosorbent assay (ELISA) for the following viral hepatitis markers: anti-HAV, anti-HAV IgM, AgHBs, anti-HBcor, anti-HBs, anti-HCV, anti-HEV IgG and anti-HEV IgM. A total of 234 patients were examined, and 1638 laboratory tests were performed. Results. The following seroprevalence levels of viral hepatitis markers were identified among patients in the urology department of SCR: AgHBs – 9.0±1.9%; anti-HBcor –47.9±3.3%; anti-HBs – 41.0±3.2%; anti-HCV – 7.7±1.7%; anti-HAV – 95.3±1.4%; anti-HAV IgM – 0%; anti-HEV IgG – 17.5±2.5%; anti-HEV IgM – 27.4±2.9%. The most affected groups for hepatitis B and C were females from the central region of the country, while for hepatitis E, males from the northern region were the most affected. Conclusions. The results indicate that urological patients can be considered a group at increased risk of infection with hepatitis B, C, and E viruses.