Contemporary myopia progression diagnosis is based on the values of spherical equivalent and antero-posterior axis growth. Physiotherapy and refractive therapy are two methods used to prevent further progression of this eye condition. Aim: to evaluate the difference between the influence of physiotherapy and refractive therapy on spherical equivalent (SE) and antero-posterior axis (APA) growth in children aged 7-16 years during a period of 36 months. Method: Clinical prospective study, that included 80 eyes in children aged 7-16 years with mild or moderate progressive myopia (mean -2,50 ± 2,24 D), 50% of which were treated with physiotherapy, 50% - which applied refractive therapy. Results: In children with mild myopia, after three years of physiotherapy, SE value increased by 1.4 times (from -1.54 ± 0.08 D up to -2.08 ± 0.13 D; p < 0.001). After 3 years of refractive therapy, SE value increased by 1.1 times (from -1.47 ± 0.08 D up to -1.68 ± 0.13 D; p > 0.05). The differences between both groups were statistically reliable (p < 0.001). In children with moderate myopia, after three years of physiotherapy, SE value increased by 1.3 times (from -3.75 ± 0.21 D up to -4.71 ± 0.26 D; p < 0.001) compared to therapy refractive, where SE increased by 1.1 times (from -3.8 ± 0.21 D up to -4.3 ± 0.26 D; p < 0.05). The differences between the data from both groups were statistically reliable (p < 0.001). In children with mild myopia, after three years of physiotherapy treatment, AAP value increased from 24.0 ± 0.08 mm up to 24.24 ± 0.13 mm (p < 0.05) compared with refractive therapy, where the same index increased from 23.92 ± 0.08 mm up to 24.0 ± 0.13 mm (p > 0.05). The differences between groups are statistically reliable (p < 0.01). In children with moderate myopia, after three years of physiotherapy, AAP value increased from 24.7 ± 0.21 mm up to 25.08 ± 0.26 mm (p < 0.05). In patients who applied refractive therapy, AAP value increased from 24.74 ± 0.21 mm up to 25.04 ± 0.26 mm (p > 0.05). The differences between groups are statistically reliable (p < 0.01). Conclusion: Both, physiotherapy and refractive therapy stop the progression of myopia in children aged 7-16 years, but the refractive therapy shows statistically better results in comparison (p < 0.001).