Refractive therapy is one of the most effective contemporaty methods of treatment and prophylaxis of the progression of myopia in children. A combination with physiotherapy has been proven to benefit the result even further. Aim: to evaluate the evolution of yearly myopia progression gradient by spherical equivalent (YMPS) and eye globe antero-posterior axis length (YMPA) under combined treatment with refractive therapy and physiotherapy. Method: Clinical prospective study, that included 80 eyes in patients aged 7-16 years with mild or moderate progressive myopia (mean -2,52±2,25 D). The treatment consisted of 3 years of refractive therapy combined with physiotherapy (electropuncture and cilliary muscle laser-stimulation during 10 days every 3 months). Results: In patients aged 7-16 years and mild myopia YMPS decreased down to 4.7% (0.04 ± 0.01 D; p<0.001) from baseline (0.86 ± 0.12 D) after 3 years of treatment. In patients aged 7-16 years and moderate myopia YMPS has reduced down to 1.7% (0.02 ± 0.01 D; p<0.001) from baseline (1.28 ± 0.22 D) after 3 years of treatment. In patients aged 7-16 years and mild myopia YMPA decreased down to 2.9% (0.01 ± 0.01 mm; p<0.001) from baseline (0.34 ± 0.08 mm) after 3 years of treatment. In patients aged 7-16 years and moderate myopia YMPA has reduced down to 1.9% (0.01 ± 0.01; p<0.001) from baseline (0.51 ± 0.12 mm) after 3 years of treatment. Conclusion: Refractive therapy combined with physiotherapy reduces statistically significant the yearly myopia progression gradient by more than 95,0%.