Introduction: Myopia management is an exciting area with new research and technology advancements that will allow us to detect the pre-myope earlier and more accurately manage pre-myopia. Material and methods: Clinical retrospective study, that included 20 pre-myopes (40 eyes) aged 6-10 years with familial factor. The combined treatment (physiotherapy and anti-fatigue lenses-Rhein Vision’s Facile) was applied for 2 years. Results: In base group with familial factor, the spherical equivalent increased (from 0.59 to -0.23 D) after 2 years of treatment, and the vitreous chamber depth increased (from 15,60 to 15,79 mm). In the control group, aged 6-10 years with familial factor the spherical equivalent has increased (from +0,66 to -0.76 D) after 2 years of treatment. The vitreous chamber depth has changed (from 16,59 to 17,02 mm) after 2 years. Between the basic group and control group, it was determined the statistical difference (p>0.05). Conclusions: Significantly higher frequency of myopia onset was determined in the control group (21% of the combined treatament vs 74% of the control).