Introduction: The International Myopia Institute defines pre-myopia as “a refractive state of an eye of ≤ +0.75 D and > -0.50 D in children where a combination of baseline refraction, age, and other quantifiable risk factors provide a sufficient likelihood of the future development of myopia to merit preventative interventions.” Material and methods: Clinical retrospective study, that included 20 pre-myopes (40 eyes) aged 11-14 years with familial factor. The combined treatment (physiotherapy and anti-fatigue lenses-Rhein Vision’s Facile) was applied for 2 years. Results: In base group with familial factor, the spherical equivalent inreased (from 0.51 to +0,01 D) after 2 years of treatment. The vitreous chamber depth increased (from 17,06 to 17,37 mm). In control group with familial factor the spherical equivalent has increased (from +0,22 to -1.11 D) after 2 years of treatment. The vitreous chamber depth increased (from 16,45 to 16,90 mm) after 2 years. Between the basic group and control group, it was determined the statistical difference (p>0.05). Conclusions: The combined treatment has been proved to be an efficient method of prevention of myopia.