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Ultima descărcare din IBN: 2024-03-24 13:37 |
Căutarea după subiecte similare conform CZU |
618.36-008.64:618.344 (3) |
Științe medicale. Medicină (11143) |
SM ISO690:2012 DAVID, Valeriu, FULGA, Veaceslav, PETROVICH, Virgil, CARPENCO, Ecaterina, ŞAPTEFRAŢI, Lilian. Ang1 immunoexpression vs vascular profile in chorio-villous germinative status in early term compromised pregnancies. In: Moldovan Medical Journal, 2023, nr. 2(66), pp. 49-55. ISSN 2537-6373. DOI: https://doi.org/10.52418/moldovan-med-j.66-2.23.08 |
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Moldovan Medical Journal | |||||||
Numărul 2(66) / 2023 / ISSN 2537-6373 /ISSNe 2537-6381 | |||||||
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DOI:https://doi.org/10.52418/moldovan-med-j.66-2.23.08 | |||||||
CZU: 618.36-008.64:618.344 | |||||||
Pag. 49-55 | |||||||
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Background: A normal maternal-fetal system is essential for the functioning of the placenta during placentation and the establishment of the maternalembryofetal vascular circulation. The angiopoietin/TIE pathway is involved in vascular morphogenesis through regulation, survival and maturation of endothelial cells concomitant with vascular remodeling. Deregulation of pro-angiogenic factor secretion and expression is associated with disruption of vascular morphogenesis, reduction of vascular bed and installation of primary placental insufficiency. The aim: Evaluation of Ang 1 immunoexpression in early term compromised pregnancies in the context of chorio-villary circulatory dysfunction in primary placental insufficiency. Material and methods: Abortion product from 61 patients (stagnant pregnancies – 39 cases, early miscarriage – 8 cases, control group – 14 cases of pregnancies solved on social indications/ desire) were immunohistochemically evaluated with the marker for anti-Ang1 and anti-CD31. Results: The villous syncytiotrophoblast was the most immunoreactive area. Most of cases of the pregnancies terminated on social indications/ desire were anti-Ang1 negative. The levels of anti-Ang1 immunoexpression were statistically significantly different in case of syncytiotrophoblast of early miscarriages and abortions terminated on social indications/ desire. The highest chorio-villous vascular density was noticed in the abortions on social indications/ desire and early misscariages group. Conclusions: The placental period is characterized by a weak angiogenic Ang1 differentiated cellular environment in the chorio-villous germinal site in the group of short term compromised pregnancies. The selectively immunoexpressed cellular profile statistically significantly correlates with placental vascular index and chorio-villous vascular density in stagnant pregnancies. |
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Cuvinte-cheie Ang1, angiogenesis, fetal conceptus, compromised pregnancies, primary placental dysfunction |
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