This floristic study was carried out during the vegetation growing season of 2023, within the limits of the "Dobruşa" landscape reserve (2,634 ha), located between the village of Olișcani and the Ciorna river, Șoldănești district. This protected area is managed by Șoldănești State Forest Enterprise, Olișcani Forest District. The main purpose of the study was to identify new data about the distribution of some rare plant species of the Republic of Moldova into this protected area. The carried out floristic research resulted in the highlighting of new places of growth for 16 rare species like: Adonis vernalis L.; Anthyllis macrocephala Wender.; Asparagus officinalis L.; Caltha palustris L.; Genista elata (Moench) Wender. [Genista tinctoria non L. auct. mold.]; Iris aphylla L.; Luzula multiflora (Ehrh.) Lej.; Potentilla alba L.; Rosa villosa L.; Scleranthus uncinatus Schur; Scrophularia umbrosa Dumort.; Scrophularia vernalis L.; Selinum carvifolium (L.) L.; Sonchus palustris L.; Veratrum nigrum L.; Vinca minor L. Two of the total identified species, are included in the Red Book of the Republic of Moldova (3rd edition, 2015) – Caltha palustris L. (EN) and Luzula multiflora (Ehrh.) Lej. (VU). At national level, seven species are protected by Law No. 1538-XIII on fund of protected areas (1998), such as: Adonis vernalis L.; Asparagus officinalis L.; Caltha palustris L.; Genista elata (Moench) Wender. [Genista tinctoria non L. auct. mold.]; Scrophularia umbrosa Dumort.; Veratrum nigrum L.; Vinca minor L. The distribution network of these species within this protected area were located by GPS, the growth points which will allow us to monitor the state of the evolution of the populations. The habitat, due to its micro-relief forms and eco-coenotic factors and provides optimal conditions for the development of these species. At the same time, in order to preserve the biodiversity of the natural ecosystems of the “Dobruşa” landscape reserve, it is necessary to develop and implement a set of measures for recording, regulating and minimizing the negative anthropogen impact.