Introduction. Polytraumas/severe traumas are can cause secondary damages to intact tissues by immunocompetent cells that infiltrate organs primarily unaffected by the traumatic agent and release proteases and/or free oxygen radicals. In this experimental study, was made an attempt to identify biomarkers for "distant" renal lesions and to develop predictive models for estimating their extent. Material and methods. In the experimental research, the conditions of a polytrauma were modeled and the concentrations of serum protease and antiprotease components described in the literature as being involved in the pathophysiology of secondary posttraumatic lesions were measured at different time intervals up to 24 hours after trauma. The correlation of the measured values with the values of renal impairment on the Assessment of Qualitative Changes with Semiquantitative Reflection Scale (AQCSRS) was evaluated to form a predictive model of them. Results. In the correlation analysis of protease/antiprotease system components with AQCSRSKIDNEY value 24 hours after traumatic impact, the score was associated with TEA2h, TEA24h, α1-antitrypsin24h, CHEA5h, CLEA0h, EEA0h and EEA2h. Some trends were also observed to correlate with TEA5h, AMPEA0h and with CGEA5h. Conclusions. AQCSRSKIDNEY positively correlated with the enzymatic activity of proteases and negatively with antiproteases, following the logic of the respective destructive and protective effects. Less characteristically, negative correlations were observed between 24-h AQCSRSKIDNEY and protease values at some time points. The explanation for the associations of "distant" renal injury with pre-trauma protease activity values may be that there is probably a balance between protective/destructive factors at this time point.