Introduction. The issue regarding the qualityoflife in patients with chronic kidney disease (CKD) has become quite important, and with a lack of data between males and females. Material and methods. There were studied 150 patients with CKD, of which 75 were men and 75 women. The diagnosis was made on the basis of clinical and paraclinical picture (glomerular filtration rate <60 ml/min/1.73 m2). The mean age of the patients was 47.5 years (18 to 77 years). The SF-36 questionnaire was used in the study. The comparison was carried out after patients were categories in different age groups: 18–27 years old (n = 8), 28–37 years old (n = 28), 38–47 years old (n = 34), 48–57 years old (n = 42), 58-67 years old (n = 22), 68-77 years old (n = 16). Results. The physical health score in males with CKD (38.4 ± 10.04) was lower than in females (41.5 ± 5.89, p = 0.0225), while the total psychological score of health in males (50.8 ± 11.31) did not differ from females (54.7 ± 17.02, p = 0.1005). The following indicators were significantly higher in males that females with CKD: physical functioning (45.4 ± 8.14 and 50.8 ± 18.77, p = 0.0237), role physical functioning (45.8 ± 4.41 and 50.3 ± 15.23; p = 0.0151), pain intensity (45.8 ± 13.86 and 50.3 ± 4.2; p = 0.0079), general health status (46.6 ± 9.85 and 50.8 ± 9.12, p = 0.0075), according to the vitality scale (12.04 ± 3.22 and 13.15 ± 2.92, p = 0.0285) and social functioning (1.24 ± 0.26 and 1.13 ± 0.35, р = 0.0305). Parameters of psychological health (10.36 ± 4.19 and 11.01 ± 5.7; p = 0.4275) and emotional health (0.64 ± 0.16 and 0.59 ± 0.31, p = 0 ,2165) in patients with chronic kidney disease in males did not differ from females. Conclusions. Males with chronic kidney disease suffer greater than females according to the physical health parameters, while the psychological health parameters show a lesser difference between sexes. Social adaptation is equally reduced in both sexes.