This paper represents a theoretical-methodological incursion on the requirements of higher education institutions to achieve sustainability. The relevance of the topic derives from the need to assess the potential of higher education institutions in order to achieve sustainability. The aim of the research is to assess the potential of universities in the context of sustainability. The paper focuses on making an approach to achieving educational performance, in terms of assessing the human, innovative potential of higher education institutions which represents a vital factor in achieving university sustainability. Universities as active actors in sustainable development must demonstrate the necessary training, competent human potential, viable educational policies, and effective tools to achieve sustainability. The research methodology focused on the use of the following methods such as: analysis, synthesis, qualitative research, scientific abstraction, which contributed to a comprehensive and complex study on the training of Moldovan universities to achieve sustainability. In conclusion, we reiterate that universities as “vectors of change” are demanded to develop successful strategies to achieve sustainability, in terms of certain effective activities that would ensure their sustainable development. The undertaken research allowed us to elucidate that Moldovan universities do not have a model for achieving university sustainability. In this context, we can point out the need to develop a viable tool for assessing the steps taken by universities to achieve sustainability.