An increased interest is actually offered in the evaluation of the impact of the new copper coordinative compounds (CCC) - thiosemicarbaside derivates. CCC showed important antitumoral properties, however their influence on the thiol-disulfide system in human erythrocytes has not been studied. The aim was to study the influence of the new copper coordinative compounds, thiosemicarbaside derivatives, coded as CMA-18, CMC-34, CMD-8, CMG-41 and CMJ-33 on the content of thiol-disulfide groups in proteins of the human erythrocytes in ex vivo experiments. As material and methods were used the new CCC, thiosemicarbaside derivatives, coded as CMA-18, CMC34, CMD-8, CMG-41 and CMJ-33 developed at the State University of Moldova in the Laboratory "Advanced materials in biopharmaceutical and technical" [1, 2, 3, 4]. In order to evaluate the influence of CCC, several ex vivo experiments were performed in which was used the peripheral blood samples collected from 8 conventionally healthy individuals. As results the research showed different changes exerted by the new CCC on the content of thiol-disulfide proteins of the human erythrocytes in conventionally healthy individuals. The most pronounced change compared to the initial level was registered for CMC-34, which significantly decreased with 47% (p<0,001). The administration of CMG41, CMJ-33 and CMD-8 diminished with 19% (p<0,001) and 17% (p<0,001) respectively in comparison with the initial level. No significant change was established by CMA-18, which remained at the same level. In conclusions the influence of studied CCC on the thiol-disulfide system indices in human erythrocytes was selective and differentiate. Further studies are needed to evaluate the mechanisms of action in other biosystems and experiments.