Root rot in plants, including straw cereal crops, is one of the most widespread and severe diseases with quite diverse manifestations. For example, in wheat, root rot is manifested by the rotting of caryopsis, primary and secondary roots, coleoptile, twining node, etc. The fungi Fusarium avenaceum and F. oxysporum are pathogens of root rot frequently encountered in wheat and in ear diseases in grass crops. Since Fusarium species, like many other micromycetes, easily adapt to the chemical preparations used in plant protection measures, the research on the identification of new compounds with antifungal activity is particularly actual. Establishing the activity of the vinyl-triazole derivative: 4-(2-(2,4-dichlorophenyl)-2-oxoethyl)-1-((2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolane) chloride -2-yl)methyl)-1H-1,2,4-triazol-4-iu against phytopathogens F. avenaceum and F. oxysporum. The vinyl-triazole derivative was supplemented to the nutrient medium Potato Dextrose Agar (PDA) in concentrations of 0,01; 0,005; 0,0025; 0.00125%. Fungal inoculation: a PDA disk with fungal mycelium of 4 mm in diameter in the center of the Petri dish. Cultivation was carried out at a temperature of 24°C. Colony diameter recording was done after sowing on the 3-5 days for the fast-growing fungus – F. avenaceum and 6-7 – for the medium-growing fungus – F. oxysporum. According to the obtained data, the vinyl-triazole derivative in the concentration range 0,01....0,005% strongly inhibited the fungi F. avenaceum and F. oxysporum, the diameter of their colonies constituting 16,3 – 25,0% and 28,6-28, 4% of the control, respectively. The high activity of the mentioned vinyl-triazole compound in relatively low concentrations reveals the high opportunities for its use in the wheat plant protection system against the root rot pathogens. This study was supported by the research projects 20.80009.5007.17 "Hybridized functionalized materials with carboxyl groups based on plant metabolites with action against human and agricultural pathogens" and 20.80009.7007.04 "Biotechnologies and genetic processes for evaluation, conservation and valorization of agrobiodiversity” funded by the National Agency for Research and Development of the Republic of Moldova.