Calves in the period of postnatal ontogenesis are largely exposed to the influence of the external environment and animal husbandry technologies. Environmental factors act on the organism in most cases conjugate and the effect of the action depends on their nature and intensity. More than that, the effects that appear after their separate or conjugate action are different and are manifested by the depth of changes in various physiological processes, which condition the development and growth of the organism. Depending on the degree of exposure to environmental conditions, the organism of newborn calves responds to the action of these factors either through adaptation reactions or through non-adaptation reactions. Researches performed on animals in the first months of life showed that during this period a large number of diseases and functional disorders of the organism are registered. Some researchers state that in the first months after birth, 2/3 of calf deaths are caused by gastrointestinal tact disorders. The main cause of these disorders is the functional immaturity of the calves, which is determined by the lack of balanced fodder and the influence of technological factors on weaned cows, as well as on calves in the first days of life. The results of the biochemical research of the calves' blood show that a considerable number of macro- and microelements are below the recommended norms or at their lower limits. It is obvious that this state strains the systems, which ensure the internal homeostasis of the organism, leads to overload, dysfunction of some systems and the appearance of various ailments (Lorenz et al., 2011). In this case the basic food ration of the calves does not ensure the normal state of homeostasis and can be classified as a moderate stressor. As a result, functional disorders and conditions appear, the correction of which requires the development of procedures that would normalize homeostasis. The study of the action of environmental factors is of particular interest for determining the parameters that can be used as a way of increasing the resistance and adaptive capacities of the animal organism to the unfavorable action of the environment. Thus, following the evaluation of the action of the studied factors, applied either separately or conjugately, on the body of the calves in the postnatal ontogenesis, it is possible to conclude that they ensure a more optimal oscillatory blood level of calcium, phosphorus, potassium, sodium and magnesium. The changing character of the level of these elements in the blood plasma of experimental animals reflects not only their quantity, which arrives in the body through the food ration, but also the peculiarities of mineral metabolism.