Large scale implementation of microbiological preparations ensures combat not only of the noxious insects but also of pathogen agents which cannot be efficiently combated by other means of biological control. The high efficiency of viral, bacterial and mycotic preparations for combating harmful insects was demonstrated in the main groups of agricultural crops which, being applied in optimal conditions against the corresponding phases. In the report the last performances in elaboration of the biotechnologies for production of the microbiological preparations, and improvement of their application technologies in the system for integrated plant protection of different groups of crops and determination of their place in these systems are much discussed. This report presents the results of state registration of 4 preparations (1 viral, 1 bacterial and 2 fungal) for combating of pest insects and phytopathogen agents.