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 SM ISO690:2012PAKHONTSU, E., GULYA, Aurelian, POIRIER, Donald, TSAPKOV, Victor I.. Coordination compounds of cobalt, nickel, copper, and zinc with N 1,N 2-bis(pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives. In: Russian Journal of General Chemistry, 2014, vol. 84, pp. 1767-1770. ISSN 1070-3632. DOI: https://doi.org/10.1134/S1070363214090217 |
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  Russian Journal of General Chemistry |
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| Volumul 84 / 2014 / ISSN 1070-3632 /ISSNe 1608-3350 | |||||||
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| DOI:https://doi.org/10.1134/S1070363214090217 | |||||||
| Pag. 1767-1770 | |||||||
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o-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1-3Cl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N 1,N 2-bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N 1,N 2-bis(pyridin-2-ylethylidene) benzene-1,2-diamine, L3 = N 1,N 2-bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0-3}. The condensation products (L1-L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of the complexes occurs in two stages: dehydration (70-95°C) and complete degradation (320-450°C). At concentrations of 10-5-10-7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells. |
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| Cuvinte-cheie anticancer activity, azomethines, coordination compounds, Schiff bases |
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