Coordination compounds of copper and nickel with N,N&prime;-[4,4&prime;- (perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)]-bis[2-(pyridin-2- ylmethylidene)hydrazinecarbothioamide] and its derivatives

Pakhontsu E.; Tsapkov Victor I.; Poirier Donald; Gulya Aurelian

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2023-10-30 10:22

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PAKHONTSU, E., TSAPKOV, Victor I., POIRIER, Donald, GULYA, Aurelian. Coordination compounds of copper and nickel with N,N′-[4,4′- (perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)]-bis[2-(pyridin-2- ylmethylidene)hydrazinecarbothioamide] and its derivatives. In: Russian Journal of General Chemistry, 2014, vol. 84, pp. 1198-1201. ISSN 1070-3632. DOI: https://doi.org/10.1134/S1070363214060231

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Russian Journal of General Chemistry

Volumul 84 / 2014 / ISSN 1070-3632 /ISSNe 1608-3350

Coordination compounds of copper and nickel with N,N′-[4,4′- (perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)]-bis[2-(pyridin-2- ylmethylidene)hydrazinecarbothioamide] and its derivatives

DOI:https://doi.org/10.1134/S1070363214060231

Pag. 1198-1201

Pakhontsu E.¹, Tsapkov Victor I.², Poirier Donald³, Gulya Aurelian²

¹ University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
² Moldova State University,
³ Université Laval, Québec

Proiecte:

Menționat în lucrare: 13.820.08.01/RoF Designul si sinteza chimică a inhibitorilor moleculari cu proprietăti biomedicale

Disponibil în IBN: 22 septembrie 2023

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Rezumat

N,N′-[4,4′-(Perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)] bis[2-(pyridin-2-ylmethylidene)-hydrazinecarbothioamide] as well as its methyl and phenyl derivatives react with copper and nickel chlorides in ethanol to form coordination compounds. In the products, the hydrazinecarbothioamides act as doubly deprotonated bridging ligands. The prepared complexes have been found to inhibit in vitro the growth and propagation of the myeloid human leukemia HL-60 cancer cells at the 10^-5-10^-7 mol/L concentration.

Cuvinte-cheie
anticancer activity, Coordination compound, Hydrazinecarbothioamide