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 SM ISO690:2012GULYA, Aurelian, TSAPKOV, Victor I., POIRIER, Donald, ARUKSANDEI, K., PAKHONTSU, E.. Sulfanilamide copper(II) chelates with 2-[(2-Hydroxyphenyl-imino)methyl] phenolom and 1-[(2-Hydroxyphenylimino)-methyl]naphthalen-2-ol. In: Russian Journal of General Chemistry, 2010, vol. 80, pp. 1351-1354. ISSN 1070-3632. DOI: https://doi.org/10.1134/S1070363210070224 |
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  Russian Journal of General Chemistry |
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| Volumul 80 / 2010 / ISSN 1070-3632 /ISSNe 1608-3350 | ||||||
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| DOI:https://doi.org/10.1134/S1070363210070224 | ||||||
| Pag. 1351-1354 | ||||||
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2-[(2-Hydroxyphenylimino)methyl]phenol (H2L1) and 1-[(2-hydroxyphenylimino)methyl]naphthalen- 2-ol (H2L2) reacted with copper(II) acetate hydrate and sulfanilamide (Sf1), sulfathiazole (Sf2), sulfaethidole (Sf3), sulfadiazine (Sf4), and sulfadimidine (Sf5) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf1-5)(L 1-2) . nH2O (n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (H2L1 and H2L 2) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf1-5) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70-90°C, followed by complete thermal decomposition (290-380°C). The complexes [Cu(Sf1)(L 1)] . 2H2O and [Cu(Sf3)(L1)] . H2O at a concentration of 10-4 M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10-5 M, whereas no antitumor activity was observed at a concentration of 10-6 M. |
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