Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: Antibacterial, antifungal and in vitro antileukemia activity

Pakhontsu E.; Fala Valeriu; Gulya Aurelian; Poirier Donald; Tsapkov Victor I.; Roshu T.

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PAKHONTSU, E., FALA, Valeriu, GULYA, Aurelian, POIRIER, Donald, TSAPKOV, Victor I., ROSHU, T.. Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: Antibacterial, antifungal and in vitro antileukemia activity. In: Molecules (Basel, Switzerland), 2013, vol. 18, pp. 8812-8836. ISSN -. DOI: https://doi.org/10.3390/molecules18088812

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Molecules (Basel, Switzerland)

Volumul 18 / 2013 / ISSN - /ISSNe 1420-3049

Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: Antibacterial, antifungal and in vitro antileukemia activity

DOI:https://doi.org/10.3390/molecules18088812

Pag. 8812-8836

Pakhontsu E.¹, Fala Valeriu², Gulya Aurelian³, Poirier Donald⁴, Tsapkov Victor I.³, Roshu T.⁵

¹ University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
² ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
³ Moldova State University,
⁴ CHUL Research Center (Université Laval),
⁵ University of Bucharest

Proiecte:

Menționat în lucrare: FQRNT Nr.115825 Synthèse et caractérisation de nouveaux complexes métal-stéroïde comme agents anticancéreux

Disponibil în IBN: 18 septembrie 2023

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Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H₂L¹-H₂L¹⁰) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C₆H₅). The characterization of the new formed compounds was done by ¹H-NMR, ¹³C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.

Cuvinte-cheie
Antileukemia, Antimicrobial activity, copper, nickel, Thiosemicarbazones, zinc complexes

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<title xml:lang='en'>Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: Antibacterial, antifungal and in vitro antileukemia activity</title>
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<subject>Antileukemia</subject>
<subject>Antimicrobial activity</subject>
<subject>copper</subject>
<subject>nickel</subject>
<subject>Thiosemicarbazones</subject>
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<description xml:lang='en' descriptionType='Abstract'><p>Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H<sub>2</sub>L<sup>1</sup>-H<sub>2</sub>L<sup>10</sup>) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C<sub>6</sub>H<sub>5</sub>). The characterization of the new formed compounds was done by&nbsp;<sup>1</sup>H-NMR,&nbsp;<sup>13</sup>C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.</p></description>
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