The paper presents the main agrochemical indexes changes: humus content, nitrate nitrogen reserves, mobile phosphorus and exchangeable potassium content in chernozem carbonated (calcareous) from south of Moldova in the period 1965 - 2015. Statistically processed data allowed to determine the dynamics of nitrogen indices with different norms: 0 - 60 - 90 - 120 - 180 kg/ha on various phosphorus funds: 1.0 - 1.5 - 2.5 - 3.5 mg/100 g of the soil. On the control variant was established that humus content decreased from 3.8% to 3.4%, nitric nitrogen reserves in soil layer of 1 m under winter wheat and maize were 67 - 102 kg/ha and decreased at the harvest to 42 - 84 kg/ha. Mobile phosphorus content decreased from 1.5 to 1.2 mg/100 g soil. Potassium exchangeable content remained at a high level of 27 - 32 mg/100 g soil. The systematic application of mineral fertilizers showed the following changes of agrochemical indices: the initial humus content was 3.8% and decreased to 3.3%, nitrate nitrogen reserves were 112 161 kg/ha in the spring and decreased insignificantly at harvest with 7 - 19 kg/ha. The mobile phosphorus content varied in dependence of applicable fertilizes norms. The exchange able potassium content slightly increased - on average by 2 mg/100 g soil.