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SM ISO690:2012 POPUSHOI, Ana. Study of the synthesis methods of 1,3-aryl(heteryl)propenone. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2022, nr. 6(156), pp. 159-171. ISSN 1814-3237. DOI: https://doi.org/10.5281/zenodo.7445813 |
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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) | ||||||
Numărul 6(156) / 2022 / ISSN 1814-3237 /ISSNe 1857-498X | ||||||
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DOI:https://doi.org/10.5281/zenodo.7445813 | ||||||
CZU: 547.7:615.2 | ||||||
Pag. 159-171 | ||||||
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In this work, we refer to the study of recent specialized literature, where some syntheses methods of chalcone derivatives are described. These substances show a very pronounced anticancer activity, having a protective action in the cellular system. They present interest due to their biological properties, such as anti-inflammatory, antioxidant, cytotoxic and antihistamine properties, etc. These important biological properties are the basis of the current research intended to obtain them synthetically. The bibliographic data refers to the synthesis of 1,3-aryl (heteryl) propenones, which are described in several reviews. The main focus is on the synthesis methods of chalcones, which allow us to obtain pure reaction products, short reaction time and high yields. Also, synthesis methods with the use of solid-based heterogeneous catalysts are described, which, in turn, are very active, durable and more economical and can be used for three synthesis cycles, without significant loss of catalytic activity. The synthesis methods studied were: aldol and crotonic condensation, Claisen-Schmidt reaction, Suzuki reaction, coupling of alkynes with aldehydes, microwave irradiation, etc. |
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Cuvinte-cheie chalconnes, condensation Claisen-Schmidt, synthesis, synthetic, Chalcone, condensare Claisen-Schmidt, sinteză, sintetic |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Popuşoi, A.</dc:creator> <dc:date>2022-12-19</dc:date> <dc:description xml:lang='en'><p>In this work, we refer to the study of recent specialized literature, where some syntheses methods of chalcone derivatives are described. These substances show a very pronounced anticancer activity, having a protective action in the cellular system. They present interest due to their biological properties, such as anti-inflammatory, antioxidant, cytotoxic and antihistamine properties, etc. These important biological properties are the basis of the current research intended to obtain them synthetically. The bibliographic data refers to the synthesis of 1,3-aryl (heteryl) propenones, which are described in several reviews. The main focus is on the synthesis methods of chalcones, which allow us to obtain pure reaction products, short reaction time and high yields. Also, synthesis methods with the use of solid-based heterogeneous catalysts are described, which, in turn, are very active, durable and more economical and can be used for three synthesis cycles, without significant loss of catalytic activity. The synthesis methods studied were: aldol and crotonic condensation, Claisen-Schmidt reaction, Suzuki reaction, coupling of alkynes with aldehydes, microwave irradiation, etc.</p></dc:description> <dc:description xml:lang='ro'><p>Prin articolul dat se prezintă studiul literaturii de specialitate, în care sunt descrise unele metode de sinteză a derivaților chalconici. Aceste substanțe au o activitate anticancerigenă foarte pronunțată, având o acțiune de protecție în sistemul celular. Ele prezintă interes datorită proprietăților biologice pe care le manifestă: antiinflamatorii, antioxidante, citotoxice și antihistaminice ș.a. Aceste propietăți biologice importante stau la baza cercetărilor actuale pentru a le obține pe cale sintetică. Datele bibliografice se referă la sinteza 1,3-aril(heteril)propenonelor, care sunt descrise într-un șir de articole de generalizare. O atenție deosebită este acordată metodelor de sinteză a chalconelor care să permită obținerea produșilor de reacție puri, timp de riacție scurt, randamente rentabile. Sunt descrise metode cu utilizarea catalizatorilor eterogeni cu bază solidă, care, la rândul lor, sunt foarte activi, durabili și mai economici și care pot fi folosiți la trei cicluri de sinteză fără pierderi semnificative ale activității catalitice. Metodele de sinteză studiate au fost: condensarea aldolică și crotonică, reacția Claisen-Schmidt, reacția Suzuki, cuplarea alchinelor cu aldehidele, iradierea cu microunde etc.</p></dc:description> <dc:identifier>10.5281/zenodo.7445813</dc:identifier> <dc:source>Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) 156 (6) 159-171</dc:source> <dc:subject>chalconnes</dc:subject> <dc:subject>condensation Claisen-Schmidt</dc:subject> <dc:subject>synthesis</dc:subject> <dc:subject>synthetic</dc:subject> <dc:subject>Chalcone</dc:subject> <dc:subject>condensare Claisen-Schmidt</dc:subject> <dc:subject>sinteză</dc:subject> <dc:subject>sintetic</dc:subject> <dc:title>Study of the synthesis methods of 1,3-aryl(heteryl)propenone</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>