The general population incidence trend in the Northern Development Region for 4 districts is increasing. It demonstrate that the quality of the environment during the studied period represented conditions for the increase in the incidence of the population. The incidence in 4 districts has a constant trend, which indicates that the quality of the environment in the given localities did not cause the increase in population incidence. The incidence in 3 districts and the municipality of Balti has a tendency to decrease, a fact that confirms that environmental conditions have ensured the trend of decreasing incidence in these localities. The results obtained regarding the anthropogenic impact on the general incidence indicate that, as a whole, in the NRD, the anthropogenic impact caused to the environment and the health status of the population can be characterized at the level that ensures a state of equilibrium in the field of the health status of the population.