Lipid status in the patients with chronic pancreatitis in relation to other risk factors
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2023-10-19 01:04
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BUGAI, Rodica, ŢÎBÎRNĂ, Ion. Lipid status in the patients with chronic pancreatitis in relation to other risk factors. In: Journal of Gastrointestinal and Liver Diseases, 2019, nr. S2(28), p. 46. ISSN 1841-8724.
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Journal of Gastrointestinal and Liver Diseases
Numărul S2(28) / 2019 / ISSN 1841-8724 /ISSNe 1842-1121

Lipid status in the patients with chronic pancreatitis in relation to other risk factors


Pag. 46-46

Bugai Rodica, Ţîbîrnă Ion
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
 
Disponibil în IBN: 24 august 2022


Rezumat

Objectives. Evaluation of lipid status in patients with different clinical forms of chronic pancreatitis (CP) in relation to other risk factors. Materials and methods. A prospective study was conducted which included 30 patients with CP, treated in the gastroenterology department of MCH „Sf. Arh. Mihail „, divided into two groups, depending on the clinical form of the CP: I group - CP with relapses (CPR); II group -patients with latent CP (LCP). I group -19 (63,3%), 10 males, 9 women, mean age-54,8 ± 2,23 years; II group-11 (36,7%), 4 males, 7 women, mean age-48,7±4,17 years. The diagnosis was confirmed by clinical and paraclinical investigations, according to the national clinical protocol. Lipid status was assessed by determining cholesterol and triglyceride levels. The AUDIT test was used for early detection of people at risk and alcohol abusers. Statistical methods used: arithmetic mean, standard deviation, arithmetic mean error. Results. The change in lipid status was determined in 20 patients, expressed by total cholesterol increase in 68,4% of patients with PCR and 72,7% of PCL; increased triglyceride levels in 78,95% of patients with PCR and 81,8% with PCL. The AUDIT test confirmed the consumption of alcohol in 17 patients (56,66%) with CP-12 men (70,6%) and 5 women (29,4%); 40% of patients reported alcohol consumption once a month or less (36,84% -CPR, 45,45%- CPL); 23,23% - 2 - 4 times a month (26,32% - CPR, 18,18% - CPL); 23,33% - 2-3 times a week (26,32% -CPR, 18,18% -CPL); 13,33% - 4 times a week or more (10,53%-PCR, 18,18% -CPL). 26,32% patients with CPR and 27,27% with CPL consume 0-2 units of alcohol in one outlet, 21,05% with CPR and 27,27% with CPL - 5-6 units; 21,05% with CPR and 27,27% with CPL - 7 - 9 units; 10,52% with CPR and 18,18% with CPL-10 or> units. The study demonstrated: In CPR at a consumption> 10 years and a dose> 150 g/day - changes in 26,32% of patients (total cholesterol increase to 1,79% and triglycerides to 21,05%, mostly in men; in CPL at alcohol consumption >10 years and dose >150 g/day there were changes in 27,27% of patients (total cholesterol increase to 18,18% and triglycerides to 27,27%). In patients with CPL, alcohol users, hypertriglyceridemia was detected in 83,3% and hypercholesterolemia in 66,7%; in CPR- hypertriglyceridemia in 81,8%, and hypercholesterolemia in 54,5% cases. Conclusions. The results demonstrated that dyslipidemias, expressed by hypercholesterolemia (72,7%) and hypertriglyceridemia (81,8%), are more common among patients with latent form of chronic pancreatitis associated with a high dose and a long alcohol consumption, predominantly among men.

Cuvinte-cheie
chronic pancreatitis, dyslipidemias