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<creators>
<creator>
<creatorName>Harea, G.G.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Lupaşco, I.A.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Dumbrava, V.A.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Chirvas, E.G.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en,ro'>Effects of steatosis on hepatic arterial hemodynamics in patients with chronic viral hepatitis C</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2016</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1841-8724</relatedIdentifier>
<dates>
<date dateType='Issued'>2016-09-20</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Hepatic steatosis, along with alcohol consumption, co-infections, is a known unfavorable factor of chronic hepatitis (CH) C progression. With the progression of liver fibrosis, portal hypertension also develops. Objective: To study arterial hepatic hemodynamics changes in patients with CH C in association with hepatic steatosis. Materials and methods: We investigated 111 patients with CH C, 56 (50.45 %) &ndash; with steatosis and 55 (49.55 %) &ndash; without steatosis. The control group included 30 healthy persons. Abdominal ultrasound was performed, with duplex Doppler examination of the portal system; with evaluation of diameter, velocities and blood flow volume of the hepatic and splenic arteries, as well as pulsatility and resistance indexes in these arteries. Results: In patients with CH C with steatosis, significant changes were found in arterial blood flow, especially in women, with concomitant steatosis: flow velocity in hepatic (90.27&plusmn;3.18 cm/s) and splenic arteries (93.18&plusmn;8.7 cm/s) was higher than in the control group (77.58&plusmn;4.70 cm/s, р&lt;0.05 and 69.89&plusmn;2.73 cm/s; р&lt;0.05 respectively). Pulsatility index in hepatic (1.58&plusmn;0.09) and splenic arteries (1.19&plusmn;0.10) was also higher than in the group without steatosis (1.18&plusmn;0.1; р&lt;0.01 and 0.85&plusmn;0.04; р&lt;0.01, respectively). In patients with CH C and steatosis a larger size of the liver caudate lobe was found (37.18&plusmn;1.63 mm) in comparison to patients without fatty liver (31.44&plusmn;1.78 mm, p&lt;0.05). Conclusions: The presence of hepatic steatosis in patients with chronic hepatitis C has a negative impact on arterial hepatic hemodynamics.</p></description>
<description xml:lang='ro' descriptionType='Abstract'><p>Introducere: Steatoza hepatică, de r&acirc;nd cu consumul cronic de alcool şi co-infecţia cu alţi viruşi, este un factor de risc recunoscut pentru progresarea hepatitei cronice (HC) virale C. Odată cu progresarea fibrozei hepatice, se dezvoltă şi hipertensiunea portală. Scopul: studierea modificărilor hemodinamicii arteriale hepatice la bolnavii cu HC C asociată cu steatoză hepatică. Material, metode: au fost examinaţi 111 bolnavi cu HC C, din ei 56 (50,45%) cu steatoză hepatică şi 55 (49,55%) fără steatoză. Lotul martor au constituit 30 persoane practic sănătoase. S-a efectuat examen ultrasonor abdominal, examinare Doppler a sistemului portal cu determinarea diametrului, vitezelor şi volumului fluxului &icirc;n arterele hepatică şi lienală, indicii de pulsatilitate şi de rezistenţă &icirc;n arterele respective. Rezultate: La bolnavii cu HC C cu steatoză s-au depistat modificări semnificative &icirc;n fluxul arterial, &icirc;n special &icirc;n lotul de femei cu steatoză asociată: viteza medie &icirc;n artera hepatică (90,27&plusmn;3,18 cm/s) şi lienală (93,18&plusmn;8,7 cm/s) au fost semnificativ mai mari ca &icirc;n lotul martor (77,58&plusmn;4,70 cm/s, р&lt;0,05 şi 69,89&plusmn;2,73 cm/s; р&lt;0,05 respectiv). Indicii de pulsatilitate &icirc;n artera hepatică (1,58&plusmn;0,09) şi lienală (1,19&plusmn;0,10) la fel au fost mai mari comparativ cu lotul fără steatoză (1,18&plusmn;0,1; р&lt;0,01 şi 0,85&plusmn;0,04; р&lt;0,01, respectiv). La bolnavii cu HC C şi steatoză hepatică s-au depistat şi dimensiuni mai mari ale lobului caudat hepatic (37,18&plusmn;1,63 mm) comparativ cu bolnavii fără steatoză (31,44&plusmn;1,78 mm, p&lt;0,05). Concluzii: Prezenţa steatozei hepatice la bolnavii cu hepatită cronică virală C influenţează negativ hemodinamica arterială hepatică.</p></description>
</descriptions>
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<format>application/pdf</format>
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