The paper provides new data about the effect of TiO₂ nanoparticles with dimensions of 40 nm on bioproduction parameters of Saccharomyces cerevisiae CNMN-Y-18 strain. According to the obtained results, TiO₂ nanoparticles added to the YPD medium in concentrations of 10, 20, 30, 40 mg/L did not seriously affect the growth of the yeast strain. The values of cellular biomass production, of total carbohydrate, mannoprotein and protein content, catalase activity fit in the range of the admissible error compared with the control. Monitoring of the evolution of biosynthetic processes in the yeast biomass in correlation with the concentration of nanoparticles is of great interest for the technologies of yeast biomass final product obtaining.