The dependence of the general incidence of the population (especially after the diseases of the respiratory system) on the degree of environmental pollution (air emissions) in the given locality is demonstrated. Diseases of the cardiovascular system remain in second place, with an average value of 194.0 / 10,000 cases and constitute 7.3 percent of the total number. This group of diseases has an increasing character, from 173.0 / 10000 in the year 2010, to (239.0 / 10000 cases towards the year 2017. The comparison of the average general prevalence on the regions of the republic indicates that the highest value, of the respective index, was registered in the North Development Region (NDR) with 7121.9 cases per 10 thousand inhabitants, followed by RD Gagauzia ATU (6969.4), on the 3rd place and 4 are placed Center DR (6954.8) and South DR with 6020.2 cases. In the structure of the general prevalence of the population in the RDN, it was established that according to the number of diseases, cardiovascular diseases are in the first place, followed by diseases: respiratory, digestive, endocrine and genitourinary diseases. The dynamics of the general mortality of the population in the Northern Development Region is established. The reduction of deaths by districts takes place in the following order: Donduseni > Briceni > Rascani > Edinet > Drochia > Ocnita > Floresti > Soroca > Sangerei> mun. Balti > RDD Chisinau. Mortality by type of disease indicates that in the first place is the mortality of diseases of the circulatory system, two – mortality caused by malignant tumors, followed by deaths caused by diseases of the digestive system, trauma and poisoning and diseases of the respiratory system. But the analysis of the trends of the main causes of death of the population in the DRN in the period 2010-2020, indicates that from 4 causes of death: diseases of the cardiovascular system, digestive system, and causes of trauma and poisoning, and tumors, indicates that for the first 3 causes of death, they have a downward trend: for cardiovascular system diseases, the downward trend is 4.6%, digestive system diseases - 24.2%, trauma and poisoning – 45.7%, and only for tumors, it is a growth trend over the entire period of 2.2%.