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Articolul urmator |
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Ultima descărcare din IBN: 2024-01-03 16:29 |
SM ISO690:2012 DIDENCU, Alexandru, ABABII, Polina, MANIUC, Mihail, DANILOV, Lucian, NACU, Viorel. Celulele autologe mononucleare importante în tratamentul rinosinuzitelor recidivante și cronice la copii. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 478. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 478-478 | ||||||
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Background. Chronic rhinosinusitis is an important problem of otolaryngology, its treatment being so far below the expected level. Objective of the study. Evaluation of immune status in children with recurrent and chronic rhinosinusitis who have received complex treatment with mononuclear autologous cells, in order to optimize standard treatment. Material and Methods. The general immunity status and the effectiveness of the complex treatment with local immunostimulation were examined by the application in the maxillary sinuses of activated autologous mononuclear cells in 19 children with chronic rhinosinusitis and 50 healthy children. Results. The presence of allergic reactions by increase in IgE and CD4/CD8 index was determined in patients examined. The inhibition of the T-cells functional decrease of T-lymphocytes in the TTBL test with phytohemagglutinin and tendency towards a decrease of the T-CD-3 lymphocytes titer. The compensatory activation of the B-cells (increase in the IgA titer) was determined. The rhinomanometric examination demonstrated an increase in total volume indices and a decrease in the total nasal resistance in all treated children. The new method of local immunocorrection whit cell terapy of chronic rhinosinusitis in children proved to be clinically effective. Conclusion. There were determined increased IgE, CD4 / CD-8 index and CIC (PEG-8% with low molecular weight), cellular sensitization to streptococcal antibodies according to TTBL data, inhibition of the T-cells and tendency towards a decrease of T-CD-3 lymphocytes. |
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Cuvinte-cheie chronic rhinosinusitis children cell therapy, rinosinuzită cronică, copii, terapie celulară |
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