This article examines the concept of occupational disease (intoxication) and its defi-ning features: the determined temporal character, the acute character, the effect character of the harmful factors of work, the prejudicial character. The research stages of the occupational disease (intoxication) are commented, as they are regulated in the Sanitary Regulation on the research and establishment of the diagnosis of occupational disease (intoxication), approved by the Government Decision of the Republic of Moldova no. 1282 of November 29, 2016: 1. signaling suspicion of occupational disease (intoxication); 2. research into the case of suspicion of occupational disease (intoxication); 3. declaring the case of occupational disease (intoxication); 4. Registration and reporting of cases of occupational disease (intoxication).