The level of economic development of the region depends to a large extent on the efficiency of using its financial resources and the intensity of the accumulation processes. An important role, therefore, is the performance of credit system management to stimulate the development of the real sector of the economy, including the development of mechanisms to maintain regional sustainability. At present for the Republic of Moldova in order to stimulate the development of the real sector of the economy, in the context of regional development, it is opportune to increase the efficiency of the activity and increase the role of the credit system. Thus, in order to streamline the activity of the credit system of the Republic of Moldova at present it is necessary to promote a monetary policy based on the correlation and adjustment of the macroeconomic, monetary and credit indicators; to achieve the objectives of monetary policy, new international approaches and practices are needed, including those recommended by international financial organizations to improve prudential supervision; the NBM is expected to have an efficient cooperation with the Government of the Republic of Moldova to ensure the real sector of the economy with sufficient investment resources.