The content of this article emphasizes the study and significance of the problem of organizational stress on mental and physical health in professional activity. The correlation between the negative factors that cause the organizational stress is highlighted, which, today, is considered a second health problem at work, the factors that positively influence the organizational process according to the respondents, which, starting from the studies and the investigative meanings based on surveys. sociological, experiment carried out by colleagues, public associations, the World Health Organization, our concerns faced by the employees in the professional activity. And in general, the existence or nonexistence of stress in the workplace and how it influences negatively or positively the mental health, the physical health and the energy level felt at the workplace.