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SM ISO690:2012 PETRENKO, Peter A., CHUMAKOV, Yurii, USATAIA, Irina, GRAUR, Vasilii О., POIRIER, Donald, TSAPKOV, Victor I., GULYA, Aurelian. Synthesis, structure, and antitumor activity of diiodo-{methyl-N-prop-2-en-1-yl-N-[1-(pyridine-2-yl)-ethylidene]carbamohydrazonothioate}zinc. In: Materials Science and Condensed Matter Physics, Ed. 8-th Edition, 12-16 septembrie 2016, Chişinău. Chişinău: Institutul de Fizică Aplicată, 2016, Editia 8, p. 189. ISBN 978-9975-9787-1-2. |
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Materials Science and Condensed Matter Physics Editia 8, 2016 |
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Conferința "International Conference on Materials Science and Condensed Matter Physics" 8-th Edition, Chişinău, Moldova, 12-16 septembrie 2016 | |||||||
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Biometal salts form with alkylated thiosemicarbazones biologically active coordination compounds with various composition and structure. The structure, physicochemical and biological properties of these substances are determined by the nature of the central atom and its ligand surroundings. Therefore, the aim of this work is the synthesis, determination of structural features and antitumor activity of diiodo-{methyl-N-prop-2-en-1-yl-n-[1-(pyridine-2-yl)ethylidene]carbamohydrazonothioate}zinc ZnLI2 (I). Complex (I) was obtained in ethanolic solution by the reaction between zinc iodide and 2acetylpyridine 4-allyl-Smethylisothiosemicarbaz one (L) taken in 1:1 molar ratio. Monocrystals of this substance were obtained by recrystallisation from ethanol. It was determined that in complex I one molecule of L and two iodide-ions are coordinated. The coordination polyhedron of the zinc atom is a distorted tetragonal pyramid. The base of this pyramid is formed by pyridinic and azomethinic nitrogen atoms, sulfur atom of the isothiosemicarbazone L and one iodine atom. The fifth coordination place is occupied by another iodine atom. The coordination by methylated sulfur atom is an unusual case. In literature sources such coordination way is found rarely and only on other central atoms [1]. The study of antitumor properties of the complex I showed that it inhibits growth and proliferation of human promyelocytic leukemia HL-60 cells in the range of concentration 10-5 -10-7M. At the concentration 10-5 mol/L it inhibits 91%, at the 10-6 mol/L - 83% and at 10-7 mol / L - 12% of tumor cells. This work was fulfilled with the financial support of the Institutional Project 15.817.02.24F. |
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