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SM ISO690:2012 POGONEA, Ina. Phagocytosis and the Effect of Imupurin. In: Curierul Medical, 2010, nr. 4(316), pp. 16-18. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(316) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 16-18 | ||||||
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The purpose of the study was to investigate a new drug of entomological origin isolated from the pupae of Lepidoptera. Experiments were
performed on young mice 18-20 g, which were divided into 3 groups: a control group and two groups that received a suspension of the drug
in the amount of 0.5 ml of saline at doses of 1000 and 100 micrograms per mouse, respectively. There was a strong stimulation of nonspecific
resistance of the organism as a result of the use of Imupurin as demonstrated by increased phagocytosis capacity of peritoneal neutrophils and
macrophages (marked increase in phagocytant neutrophils and macrophages, namely reducing the nonphagocytant). The results showed that in
doses of 100 and 1000 micrograms Imupirin increased the number of phagocytant neutrophils by 3.16 and 3.49 times and increased the number
of phagocytant macrophages by 3.66 and 3.55 times, respectively, compared to the control. The observed effects of the entomological drug did
not depend on the dose, which indicates that the effects on phagocytosis depend mainly on the composition of Imupurin (proteins, lipids) and
to a lesser extent on the quantity. |
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Cuvinte-cheie imupurin, nonspecific resistance, phagocytosis, nymph, immunostimulation |
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