Macroeconomic risks have a complex effect on the level of business activity, liquidity and financial stability of the economy of the Republic of Moldova. Risks and vulnerabilities can develop endogenously within the financial system, but can also occur in the real economy and be transferred to the financial system. The systems approach determines the reform of the macroeconomic risk management system as part of the strategic planning process for the development of the banking sector, the financial system and the country as a whole. The methodology used to calculate indicators of the macroeconomic risks were based on IMF methodology. Authors conclude that Moldova’s is lagging in terms of per capita income and weak social development emphasizes the need for faster and more comprehensive growth. However, the existence of an export-oriented economy development model, along with a weak financial system, makes the real sector vulnerable to external shocks and does not allow for a sustainable economic growth.