This article presents the results of analysis of the particularities connected with the formation and development of national and regional labour markets of the Republic of Moldova. The research is based on statistical data on the number of the resident population and the population with usual residence, which reflects the real situation in the country, taking into account the population, that absence of more than a year. Evaluation of impact of demographic factors, including the population decline, the change in the age structure and demographic ageing, and migration processes, was given in the analysis of labour force market and the possibility of its reproduction. Economic factors have importance for the stable development of labour force market, including the state of production and social structures in regions, the development of different forms of property, the quality of professional training of labour force, as well as the level of remuneration or wage. As a result of a comparative analysis of the situation in the regional aspect, the main challenges of labour market were identified. The proposals to improve the socio-economic policies were developed, including to increasing of employment rate of working age population, reducing the regional differentiation of local labour markets, promoting new perspective forms of remuneration and, as a result, increasing the stability and sustainability of the above markets to exogenous and endogenous factors.