Among the many environmental problems that threaten the Blue Planet, waste and garbage is a major one. With the population explosion and the revolutions in agriculture and industry, waste has exceeded the capacity of the environment to absorb and neutralize at a rate close to the rate at which it is generated. The worst effects of poor management of this waste are air pollution and contamination of drinking water reserves, which leads to increased incidence of disease by pathogens. In the Republic of Moldova, the waste problem remains unresolved, and a number of management issues requires a stringent intervention on behalf of public authorities. This article focusses on municipal waste problem in the Republic of Moldova, starting with problems of localities’ sanitation in urban areas, waste storage, increase of unauthorised landfills, as well as lack of administrative capacities in elaboration and implementation of a complex program of actions for solid and liquid waste management in the country.