We find that in the last decades the pace of growth of economic indices of the wine chain, both worldwide and in the Republic of Moldova, are modest or even perplexing. Facing the stiff competition from new wine-growing countries, which have proven faster in occupying free niches on the market, Moldova continues to restructure the branch within the National Office of Vine and Wine, continues to modernize its equipment and adjust documentation to EU requirements, and continues to fight for improvement of production quality. This, the last desideratum, remains the main one in the hierarchy of problems that invaded the branch with the phenomenon of globalization. The manufacturer is no longer as protected as before, as multifactorial competition with electronic homo-presence has emerged. Internet support in promotion and trade is felt everywhere. The crisis is not so much in the volume of production, but in its presentation: the audio-visual impact, the cultural-tourist review comments, the editing of the infogenerating materials of the image and the reputation of the producers in front of the consumers. In this context, many desperately needed investors are also attracted in Moldova. The globalization of wine does not scare us, but it requires us to react to those factors on which the economy and the market depend.