Structural reforms, modifications in economic and social infrastructure following the promotion of market mechanisms, demographic factors (population’ decline, structural modification and ageing, migration) have affected the development of the regions in different modes. Some regions have managed to rebuild successfully and their economic growth is noticeable, others are still in a state of economic stagnation. All this has contributed to regional inequality, the attenuation of which requires the solution of socio-economic problems and channelling additional financial sources. Taking into account that employment is an important factor in ensuring stable socio-economic development, the analysis of the possibilities of the population to be employed and the risk of unemployment, income levels, identifying the factors that contribute to labour migration was carried out. Based on the results of the research, several proposals have been elaborated to perfect socio-economic and employment policies, including ensuring equal development of regions, increasing the employment level of working age population, including also of migrants returning to the country, improving the system of labour remuneration, which will contribute to attenuation regional differentiation and convergence in the future. The article was elaborated within the framework the project of the State Program (2020-2023) 20.80009.0807.21 Migration, Demographic Changes and Policies of Stabilization the Situation.