Self-employment is the way that allows people to harmonize their work experience with specific personal needs and create a personalized, adapted, flexible and optimal environment. Self-employment can facilitate active social and economic inclusion, and enable disabled people to obtain and control flexibility in workload, working hours and workplace, thus providing adequate leverage in coping with disabi-lity. Strategies and policies for the social and economic inclusion of people with disabilities have become a priority in the European Union and serve as a model for the adequate and multilateral conception of inclusion. During the carried out research, the views of various researchers and the experience of the European Union in the field of inclusion and self-employment of people with disabilities were analyzed. The presented conclusions and recommendations aim to facilitate this process in the Republic of Moldova.