This work describes and presents methods for the synthesis of hydroxymethylphthalocyanines of transition metals (zinc, iron) and the possibility of grafting them to copolymers of N-vinylpyrrolidone (N-VP) with acryloyl chloride (Acl) to obtain environmentally friendly polymers for photodynamic therapy: Hydroxymethyl phthalocyanines were obtained by hydroxymethylation of corresponding phthalocyanines in the presence of urotropine. Copolymer (N-VP):(ACl) were obtained by polymerization of N-vinylpyrrolidone and acryloyl chloride in the presence of 2.0% azo-bis-isobutyronitrile, at a temperature of 80° C for 4 hours, the ACl content was 10, 20 and 30 mol %. The obtained copolymers were purified by sedimentation from hexane. The intrinsic viscosity of such copolymers range from 0.06 to 0.10. The grafting of hydroxymethyl phthalocyanines to copolymer (N-VP):(ACl) was carried out in carbon tetrachloride in the presence of triethylamine. The chemical structure of the copolymers (N-VP): (ACl), as well as the polymer analogs with hydroxymethyl phthalocyanines (N-VP): (AOCH2Phc) was confirmed from the IR spectrum data. UV-VIS spectrum data and find toxicity at the molecular level for polymers (NVP):( AOCH2Phc) suggests that these materials are prerequisites for further tests of photodynamic activity.