In this article is approched perspective of incrimination the separatism as a crime in
the criminal law of the Republic of Moldova. This phenomenon, which often occurs on the basis
of artificial premises, seriously undermines the independence, external and internal security of
the state. Also, separatism is a shutter mechanism of regional wars and military conflicts that
involves multiple victims. Starting from these premises in this article was concluded that for
effective prevention of separatism is required to incriminate it in criminal law.