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SM ISO690:2012 TACU, Lilia, KOBETS, Valery. Diastolic disorder inherent to doxorubicin cardiotoxicity. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 46. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 46-46 | ||||||
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Rezumat | ||||||
Background. Doxorubicin (Dx), antibiotic of anthracycline group, used with predilection in treatment of oncologic diseases, often results in cardiotoxicity manifested by endangering diastolic relaxation, which requires cessation of its administration. Objective of the study. Evaluation in vitro the endangering nature of diastolic relaxation under the action of doxorubicin (Dx). Material and Methods. It has been analyzed 2 groups: control and with Dx, of 9 white laboratory mice per group. On the perfused isolated heart in isovolemic regime (method Langendorff) and work regime (method Neely -Rovetto) has been estimated the lusitrope function of left ventricle (LV) in course of different hemodynamic and neuroendocrine exercise tests in both groups. Results. The initial changes of diastole were imposed by increasing the end diastolic pressure of left ventricle (EDLVP) (10,4±0,7 vs 7,1±0,6 mmHg) and by decreasing isovolumic relaxation velocity (-dP/dTmax) of the heart (6120±130 vs 7490±195 mm Hg/sec). The increasing cumulative dose of Dx led to impairment of diastole in physiologic regime of the perfused isolated heart: EDLVP (12,6 ±0,78 vs 4,7±0,26 mmHg) and value of -dP/dT max(5045±120 vs 6710±174 mmHg/sec), dubling of diastolic stiffness (62,5±4,4 vs29,8±1,7 mm Hg/ml). Cardiotoxicity of Dx has been marked by higher values of EDLVP under the increasing LV volume, that led to coronary flow decline (7,6±0,5 vs 9,7±0,6 ml). Conclusion. Functionally, cardiotoxicity of Dxis imposed by diastole disorder, the incipient manifestations of reduced diastolic reserve, are being increased EDLVP, decreased dP/dT max and impairment of volume – pressure relation of LV, which depreciate coronary perfusion. |
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Cuvinte-cheie doxorubicin, cardiotoxicity, diastolicstiffness, coronaryflow, doxorubicină, cardiotoxicitate, rigiditate diastolică, flux coronarian |
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