This study aims to analyze the peculiarities of international population migration in the Northern Development Region (NDR), an area located in the northern extremity of the Republic of Moldova, which includes a stable population of 974,558 inhabitants (2019) concentrated in 3 municipalities (Balti , Edinet, Soroca) and 11 districts (Briceni, Edinet, Donduseni, Drochia, Falesti, Floresti, Glodeni, Ocnita, Riscani, Singerei, Soroca). NDR is subject to a real demographic decline (being the most affected region in the country), characterized by a negative natural balance (continuous decline in the birth rate and high mortality rate), an aging and accentuated depopulation, these being supported by an intense internal and international migration. On the whole, in the post-war period the phenomenon of migration was mainly focused on an internal migration (village-city). However, after the independence of the Republic of Moldova (1991) and the opening of the borders to the west, internal migration gradually turns into an international migration. Over time, external migration has been divided, geographically, into two distinct directions: the migratory flow to the CIS states, which is largely part of the currently declining temporary labor migration, and the flow to the European Union states, which from temporary circulatory migration, has gradually turned into long-term or permanent migration. The global pandemic situation has affected migration in both directions, its intensity being considerably diminished. This international dynamic of migration leads to essential changes in the regional demographic structures, especially through the erosion of the 25-35 age group (aspect highlighted by the reduction of the active labor force). Thus, in the medium and long term the NDR will face a pessimistic scenario in terms of socio-economic status (development, infrastructure modernization) without taking clear measures of administrative-territorial officials, to mitigate the demographic decline and reduce the phenomenon of international migration.