Novelty of this investigation is determined by the desirability of defining the national interest of the Republic of Moldova as factor of development and ensures of the society cohesion, taking as a basic interconnection and interdependence of domestic politics and foreign policy. Defining of its national interests stand for Republic of Moldova as an opportunity to demonstrate that is committed to fulfilment with the values of freedom and tolerance, are opened to dialogue and bi-multilateral cooperation. Thereby Republic of Moldova tends to turn into a generator of security and reliable partner, and get on these course more audience and credibility. National interests of the Republic of Moldova are mostly regional, as its potential political and economic is limited and therefore cannot claim the overall roles and functions in the world arena. In addition, it is in a "gray" area of insecurity and instability at the same time as political-military, and ethno- confessional, which requires further efforts to strengthen its positions.