Republic Moldova possess few energy resources, so being forced by the importing near 95% of necessary, and totally depending on supplying countries, that’s all determining the policy orientation of researches and innovation with the target of discovering new energo-resources, the main being the production of vegetable biofuels, based on productivity analysis, environmental impact, economic effi ciency and which will not affect the ensuring the people with food. Economic value, and botanical peculiarities (vigorous rooting, soil protection, restoration of soil structure) provide perspectives for species cultivation, as follow: Polygonum sachalinense Fr. Schmidt (Fallopia sachalinensis, Reynoutria sachalinensis), Silphium perfoliatum L., Sida hermaphrodita Rusby (Virginia fanpetals,V. mallow, Napaea hermaphrodita), Galega orientalis Lam., Helianthus tuberosus L., Phalaris arundinacea L. of 15-20 years longevity. Cultivation and harvesting of these species do not need sophisticated mechanisms and specifi c equipment as in forest exploitations, ensuring a high quantity of dry biomass: 10-23 t / year / ha with great caloric value - 17 to 19 MJ / kg. Energy potential of these plants can be developed in three main directions for obtaining bio-ethanol, biogas, briquettes or pellets, being transformed into energy.