Fresh fruits and vegetables and the grains are important components for a healthy and equilibrate diet and represent a valuable source of vitamins and minerals. At present, the global population growth led, inevitably, to an increase in demand for food, especially agro – food products. Thus, to obtain a stable and mass production of agricultural products the use of pesticides is required. Pesticides are toxic substances released intentionally into environment to decimate different kinds of pests (weeds, insects, fungus, rodents), that may affect large areas of agricultural production. However, intensive use of pesticides has resulted in an increase of residual pesticides content in foods based on vegetables, fruits and grains. The studies performed over the last decade had shown that residual pesticides causes serious health problems. This study present a several new technologies which can be effectively applied on agriculture products to minimize the risk of pesticide on human health.