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SM ISO690:2012 STĂVILĂ, Natalia, OLEINEAC, Cristina, ŢURCANU, Adela, STĂVILĂ, Natalia. Hemoragia gastrică în boala Rendu-Osler. In: Sănătate Publică, Economie şi Management în Medicină , 2013, nr. 5(50), pp. 58-62. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 5(50) / 2013 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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Pag. 58-62 | ||||||
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Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal-dominantly inherited disease caused by heterozygous mutations in the genes involved in the transforming growth factor-β family signaling cascade that occurs in approximately one in 5000 to 8000 people. The gastrointestinal bleeding is the most frequently type of bleeding met after epistaxis, in the patients suffering from HHT. In this article we highlight the modern view of the physiopathology, clinical and laboratory diagnostic and treatment of HHT. Therefore we focus on the involvement of gastrointestinal tract in patients with HHT. We also report here a case of a patient suffering from HHT, developing inappropriate clinical manifestations, evaluated and managed in our hospital. Although, the gastrointestinal involvement in patients with HHT occurs particularly in later years, it is a common manifestation that needs prompt therapeutical interventions, unless having fatal consequences for the patient. |
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Cuvinte-cheie hereditary hemorrhagic telangiectasia, gastrointestinal bleeding, epistaxis, наследственная геморрагическая телангиэктазия, желудочно-кишечные кровотечения, болезнь Рандю-Ослера |
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