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<creators>
<creator>
<creatorName>Zhabinskii, V.N.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Hurski, A.L.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Laktsevich-Iskryk, M.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Kukel, A.G.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Liubina, A.I.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Baradzenka, A.G.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Straltsova, D.</creatorName>
<affiliation>Universitatea de Stat din Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Demidcic, V.</creatorName>
<affiliation>Universitatea de Stat din Belarus, Belarus</affiliation>
</creator>
<creator>
<creatorName>Drasar, P.</creatorName>
<affiliation>University of Chemistry and Technology Prague, Cehia</affiliation>
</creator>
<creator>
<creatorName>Khripach, V.A.</creatorName>
<affiliation>Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Belarus</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>C-H functionalization of brassinosteroids</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2019</publicationYear>
<relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'>978-9975-62-428-2</relatedIdentifier>
<dates>
<date dateType='Issued'>2019</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Brassinosteroids are hormones that regulate numerous biological processes in plantsincluding growth, reproduction and resistance to stresses [1]. These steroids are available only synthetically and their preparation is a laborious task. Nevertheless, such brassinosteroids as 24-epibrassinolide and 24-epicastasterone are used in agrochemistry and efficient protocols for their preparation on kilograms scale have been developed. Conjugates of brassinosteroids with fluorescent dyes are demanded in chemical biology for visualization of biochemical processes. An important issue in the design of the conjugates is that after the chemical modification, biological activity of a modified steroid should be similar to that of the parent molecule. As far as functional groups in brassinosteroids are responsible for biological activity, we decided to prepare conjugates in which a linker would be connected to the hydrocarbon skeleton of the molecule. Although total synthesis of steroids with a modified core still remains a challenging task, significant progress in the regioselective modification of complex molecules by means of direct C-H bond functionalization has been achieved recently [2]. Two regioselective C-H activation-based methods for derivatization of readily available 24-epibrassinolide and 24-epicastasterone will be presented in the current communication. Our first approach is based on the rhodium-catalyzed C-H amination that enabled the preparation of C15-functionalized brassinosteroids [3]. An alternative method of hydroxyl-directed 1,5-hydrogen atom transfer was utilized to prepare C19-modified 24-epicastasterone. All of the obtained derivatives of brassinosteroids were successfully transformed to the conjugates with BODIPY dyes.</p><p>formula</p></description>
</descriptions>
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