The coordination chemistry of the transition metal complexes with thiosemicarbazide derivatives has been widely investigated due to their attractive chemical, physical and biological properties. Employing various thiosemicarbazide derivatives and different metal ions with different oxidation states allows the preparation of a wide number of coordination compounds with original structures and properties.    In this work we present a new way of activization of thiosemicarbazide fragment and his condensation product with salicylaldehyde - thiosemicarbazone by coordination to the transition metals. An interesting point is to functionalize the salicylaldehyde thiosemicarbazone with strong ionic group for increasing the solubility in water solution of product.    We study the functionalisation of salicylaldehyde thiosemicarbazone with strong ionic group for increasing the solubility in water solution of resulting products.  For this, we functionalize the five position of the salicylic fragment by the cationic group like N+(CH3)3 and anionic group like NaSO3. First, was synthesized the corresponding salicylic aldehyde, and after his condensation products with N4 - substituted thiosemicarbazide. Finally a series of new ionic ligands with high solubility in water solution was obtained. All ligands were characterized by IR and RMN spectroscopy.   The obtained ligands were used for the synthesis of new coordination compounds with 3D transition metals. For each type of metal compounds is necessary to find the special synthesis conditions. For manganese chemistry is necessary to obtain the precursor in a strong basic medium and after promoting the oxidation reaction in different solvents. For copper compounds in function of the pH- area were obtained materials with protonate, molecular or deprotonate thiosemicarbazone in the crystal structure. The influence of carbonyl fragment substituent and pH on the crystal structure, magnetic, analytical and biological properties was investigated.   Acknowledgements: The authors thanks Erasmus Mundus scholarship program, CIM- Centre for International Migration and Development and ASM, USM and Supreme Council for financial support, projects: 15.817.02.28F and 15.819.02.04F.