Atherosclerosis is one of the etiological factors to initiate degeneration disc studied in detail by histological investigations stained with haematoxylin-eosin and immunohistochemical examination with antibodies CD34, in immunohistochemical laboratory from Timisoara, leader Marius Raica. Were examinated of 20 sample harversted from the L1-L5 vertebral arteries from cadavers with different cardiac pathologies as a couse of a death, age and sex from "Sfînta Treime" hospital. Atherosclerosis with vascular wall thickening affects the structureand viability of intervertebral disc, initially being affected nucleus pulposus, annulus fibrosis and then through a series of mechanisms it splits fragmented collagen fibers, and finally fibroblast proliferation with sclerosis. In five cases the vertebral arteries were affected, lacking intimate vascular event (5%), in three cases, faint, moderate; in ten cases-handed (50%), and in 6 casespreserved. Currently modern technologies remain in the assessment of new methods of treatment and prevention of degenerative-dystrophic changes.